Endoxifen (Z-isomer)

SKU: orb1305808

Description

Endoxifen (Z-isomer) is the primary active metabolite of tamoxifen, exhibiting superior estrogen receptor affinity and specificity while also acting as an aromatase inhibitor. It is a critical research tool for studying breast cancer therapeutics in both in vitro and in vivo models.

Research Area

Cardiovascular Research, Metabolism Research, Pharmacology & Drug Discovery, Signal Transduction

Key Properties

• CAS Number: 112093-28-4
• MW: 373.49
• Purity: 99.81% (May vary between batches)
• Formula: C₂₅H₂₇NO₂
• SMILES: CC\C(=C(/c1ccc(O)cc1)c1ccc(OCCNC)cc1)c1ccccc1
• Target: Estrogen Receptor/ERR,Potassium Channel,EGFR,Estrogen/progestogen Receptor
• Solubility: DMSO:45 mg/mL (120.49 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (5.35 mM)

Bioactivity

• Target IC50:
  ERG (human):1.6 μM

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Z-isomer, progestogen Receptor, progestogenReceptor, PotassiumChannel, Potassium Channel, KcsA, inhibit, ER, ERR, Endoxifen Z-isomer, Endoxifen (Z isomer), Endoxifen (Zisomer), Endoxifen, Endoxifen (Z-isomer), Estrogen Receptor, EstrogenReceptor, Estrogen Receptor/ERR, Inhibitor, hERG, hERG Potassium Channel

Compound Identifiers

PubChem CID

10090750