Endoxifen (E-isomer)

SKU: orb1309702

Description

E-Endoxifen is the trans-isomer of (Z)-Endoxifen and acts as an antiestrogen. It is a research-grade small molecule used in vitro and in vivo to study breast cancer therapeutics and estrogen receptor signaling pathways.

Research Area

Metabolism Research

Key Properties

• CAS Number: 114828-90-9
• MW: 373.49
• Purity: 98.57% (May vary between batches)
• Formula: C₂₅H₂₇NO₂
• SMILES: C(=C(\CC)/C1=CC=CC=C1)(\C2=CC=C(OCCNC)C=C2)/C3=CC=C(O)C=C3
• Target: Estrogen Receptor/ERR
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:1 mg/mL (2.68 mM);DMSO:30 mg/mL (80.32 mM)

Bioactivity

• In Vitro:
  Endoxifen exists as the potently anti-estrogenic (Z)-isomer and the lesser-known (E)-isomer. (E)-Endoxifen is identified as the primary degradant. The (E)-isomer is an impurity in (Z)-Endoxifen drug substance and increases under certain storage conditions.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

ERR, E-Endoxifen, E-isomer, Endoxifen, Endoxifen (E isomer), Endoxifen (Eisomer), Endoxifen (E-isomer), Endoxifen E-isomer, Estrogen Receptor/ERR, EstrogenReceptor, Estrogen Receptor, inhibit, Inhibitor

Compound Identifiers

PubChem CID

3035980