Endovion

SKU: orb1218246

Description

Endovion is a pharmacological anion channel and an Anoctamin-1 (ANO 1) channel inhibitor. Endovion is also the specific VRAC/VSOAC blocker.

Key Properties

• CAS Number: 265646-85-3
• MW: 495.18
• Purity: >98% (HPLC)
• Formula: C₁₆H₉BrF₆N₆O
• SMILES: O=C(Nc1cc(C(F)(F)F)cc(C(F)(F)F)c1)Nc(cc(cc1)Br)c1-c1n[nH]nn1
• Target: Chloride Channel
• Solubility: DMSO:120 mg/mL (242.34 mM; Need ultrasonic);H2O:< 0.1 mg/mL (insoluble)

Bioactivity

• In Vitro:
  Western blot analysis. Cell line: Wild-type, resistant, and transiently transfected A2780 cells. Concentration: 10-100 μM. Incubation time: 18 or 4.5 h. Result: Reduced the maximal taurine rate constant more than 90% compared with the untreated control cells. Resulted in an increased LRRC8A protein expression. Significantly reduced p53 and p21Waf1/Cip1 protein level in A2780WT cells. Cell Proliferation Assay. Cell line: Capan-1, AsPC-1, BxPC-3 and H6c7 cell lines. Concentration: 10 μM. Incubation time: 24 h. Result: Resulted in the most pronounced inhibition in all cell lines with 77 ± 26% in Capan-1, 67 ± 9% in AsPC-1, and 54 ± 8% in BxPC-3 cells at +67 mV.
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Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

NS3728

Quick Database Links

Gene Symbol

Chloride Channel