β-Endorphin (human)

SKU: orb3054007

Description

β-Endorphin, human, a prominent endogenous peptide, existing in the hypophysis cerebri and hypothalamus,and is an agonist of opioid receptor.

Key Properties

• CAS Number: 61214-51-5
• MW: 3464.98
• Purity: >98% (HPLC)
• Formula: C₁₅₈H₂₅₁N₃₉O₄₆S
• Target: Opioid Receptor
• Solubility: DMSO : 100 mg/mL (28.86 mM; ultraphonic; ) H2O : ≥ 50 mg/mL (14.43 mM)

Bioactivity

• In Vitro:
  β-Endorphin, human is an agonist of opioid receptor, with preferred affinity for μ-opioid receptor and δ-opioid receptor. β-Endorphin exhibits anti-nociception activity by stimulating ε-opioid receptor, rather than μ-, δ-, and κ-opioid receptor. β-Endorphin has anti-nociception activity. Firstly, β-Endorphin combines together with the opioid receptors in hyperalgesia. Further, β-Endorphin suppresses the release of substance P at the level of spinal cord and blocks the conduction of pain on the primary sensory neurons. Moreover, β-Endorphin activates the endogenous analgesia system located in the CNS. In addition, β-Endorphin inhibits the conduction of pain and agitation of nociceptors to exert an analgesic effect.

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

Opioid Receptor