Enbezotinib

SKU: orb1687756

Description

Enbezotinib is a potent and selective RET kinase inhibitor that blocks its autophosphorylation. It is a valuable research tool for investigating RET-driven cancers, such as non-small cell lung cancer and thyroid cancer, in both in vitro and in vivo models.

Research Area

Cell Biology, Signal Transduction

Key Properties

• CAS Number: 2359649-81-1
• MW: 424.43
• Purity: 99.84% (May vary between batches)
• Formula: C₂₁H₂₁FN₆O₃
• SMILES: [H][C@]12CCC[C@@]1([H])N1Cc3cc(F)cnc3O[C@@H](C)CNC(=O)c3cnn4cc(O2)c1nc34
• Target: c-RET
• Solubility: DMSO:90 mg/mL (212.05 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:3.3 mg/mL (7.78 mM)

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

RET, cRET

Compound Identifiers

PubChem CID

146662764