Enalapril Maleate

SKU: orb1300726

Description

Enalapril Maleate (MK-421 Maleate) is an ACE inhibitor used in research on hypertension, heart failure, and diabetic nephropathy. It is widely applied in both in vitro enzymatic assays and in vivo animal models to study the renin-angiotensin system and cardiovascular pathophysiology.

Research Area

Metabolism Research

Key Properties

• CAS Number: 76095-16-4
• MW: 492.52
• Purity: 99.54%
• Formula: C₂₀H₂₈N₂O₅·C₄H₄O₄
• SMILES: OC(=O)\C=C/C(O)=O.CCOC(=O)[C@@H](CCc1ccccc1)[C@]1(CCCN1C(=O)[C@H](C)N)C(O)=O
• Target: Angiotensin-converting Enzyme (ACE),RAAS
• Solubility: Ethanol:4 mg/mL (8.12 mM);H2O:< 1 mg/mL (insoluble or slightly soluble);DMSO:6.88 mg/mL (13.97 mM)

Bioactivity

• In Vivo:
  Enalapril treatment abolishes the deleterious effects of eNOS deficiency on blood pressure (BP), atherosclerosis, and kidney dysfunction in nnee mice. Enalapril causes a dose-dependent increase in fore limb strength in the mdx mouse. Enalapril causes a dose-dependent reduction of superoxide anion production in tibialis anterior muscle of the mdx mouse as observed by dihydroethidium staining. Enalapril (5 mg/kg) reduces the area of muscle necrosis in both gastrocnemious muscle and diaphragm, without significant effect on non-muscle area. Enalapril Maleate results in significant increases in kidney weight and in concentrations of urinary albumin, N-acetyl-fl-d-glucosamidase (NAG) and serum ET-1 in streptozotocin (STZ)-induced diabetic (STZ-DM) rats as compared with the non-diabetic rats, and the concentration of ET-1 in the kidneys tended to be increased. Enalapril Maleate results in increased mesangial cell proliferation, matrix expansion and enlarged mesangial area in the kidney of the diabetic rats. Enalapril Maleate reduces increased concentrations of urinary albumin and NAG in the STZ-DM rats to the control values with a slight improvement in the electron microscopic changes.
• In Vitro:
  Enalapril is rapidly converted by ester hydrolysis to enalaprilat, a potent ACE inhibitor; Enalapril itself is only a weak ACE inhibitor. Enalapril lowers peripheral vascular resistance without causing an increase in heart rate.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Renitec Maleate, Vasotec Maleate, Inhibitor, inhibit, MK 421, MK 421 Maleate, MK421, MK-421, MK-421 (maleate), MK421 Maleate, MK-421 Maleate, Enalapril, Enalapril Maleate, Glioten Maleate, ACE, Angiotensin-converting Enzyme (ACE)

Compound Identifiers

PubChem CID

70054240