EN6

SKU: orb1309705

Description

EN6 is a small-molecule, in vivo autophagy activator that covalently modifies the v-ATPase subunit ATP6V1A at Cys-277. This modification inhibits mTORC1 signaling, enhances lysosomal acidification, and promotes the clearance of protein aggregates like TDP-43, relevant to frontotemporal dementia research.

Research Area

Cell Biology, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 1808714-73-9
• MW: 368.34
• Purity: 97.04% (May vary between batches)
• Formula: C₁₉H₁₄F₂N₄O₂
• SMILES: Fc1ccc(NC(=O)c2cnn(c2)-c2ccccc2F)cc1NC(=O)C=C
• Target: Proton pump,Autophagy
• Solubility: DMSO:5.43 mg/mL (14.74 mM);Ethanol:1.1 mg/mL (2.99 mM)

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Autophagy, inhibit, Inhibitor, EN 6, EN6, EN-6, Proton Pump, Proton pump, Protonpump

Compound Identifiers

PubChem CID

99640033