EN6

• Catalog Number: orb1309705
• Category: Small Molecules
• Description: EN6
• Purity: 95.16%
• MW: 368.34
• Biological Activity: EN6-mediated ATP6V1A modification decouples the v-ATPase from the Rags, leading to inhibition of mTORC1 signaling, increased lysosomal acidification and activation of autophagy. EN6 clears TDP-43 aggregates, a causative agent in frontotemporal dementia, in a lysosome-dependent manner. EN6 is a small-molecule in vivo activator of autophagy that covalently targets cysteine 277 in the ATP6V1A subunit of the lysosomal the vacuolar H+ ATPase (v-ATPase).
• CAS Number: [1808714-73-9]
• Formula: C₁₉H₁₄F₂N₄O₂
• SMILES: Fc1ccc(NC(=O)c2cnn(c2)-c2ccccc2F)cc1NC(=O)C=C
• Storage: -20°C
• Note: For research use only