Emzadirib

SKU: orb1708701

Description

Emzadirib (RAD51-IN-2) is a potent small molecule inhibitor targeting the RAD51 protein, a key mediator of homologous recombination DNA repair. Its application in research includes studying DNA damage response mechanisms in vitro and evaluating its potential as a chemosensitizer in cancer models, both in cellular and preclinical settings.

Research Area

Cell Biology, Molecular Biology

Key Properties

• CAS Number: 2301085-04-9
• MW: 580.76
• Purity: 99.79% (May vary between batches)
• Formula: C₂₇H₄₀N₄O₆S₂
• SMILES: CC(C)OC(=O)N[C@H]1CC[C@@H](CC1)c1ncc(s1)-c1ccc(NC(=O)OC(C)C)cc1S(=O)(=O)NC(C)(C)C
• Target: DNA/RNA Synthesis
• Solubility: DMSO:80 mg/mL (137.75 mM)

Bioactivity

• In Vitro:
  The EC50 values in various cell lines with different expression levels of activation-induced cytidine deaminase (AICDA) indicate good activity in the Daudi, U-698-M, and CCRF-SB cancer cell lines.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

DNASynthesis, DNA Synthesis, CYT-0851, RNASynthesis, RNA Synthesis, RAD51-IN-2, RAD51IN2, RAD-51-IN-2, RAD51, RAD51 IN 2

Compound Identifiers

PubChem CID

137542570