Emamectin Benzoate

SKU: orb1218743

Description

Emamectin Benzoate, by binding gamma-aminobutyric acid (GABA) receptor and glutamate-gated chloride channels disrupting nerve signals within arthropods, acts as a chloride channel activator.

Key Properties

• CAS Number: 155569-91-8
• MW: 1880.33
• Purity: >98% (HPLC)
• Formula: C₁₀₄H₁₅₄N₂O₂₈
• SMILES: CC[C@H](C)[C@@H]1[C@H](C=C[C@@]2(O1)C[C@@H]3C[C@H](O2)C/C=C(/[C@H]([C@H](/C=C/C=C/4\CO[C@H]5[C@@]4([C@@H](C=C([C@H]5O)C)C(=O)O3)O)C)O[C@H]6C[C@@H]([C@H]([C@@H](O6)C)O[C@H]7C[C@@H]([C@H]([C@@H](O7)C)NC)OC)OC)\C)C.C1=CC=C(C=C1)C(=O)O
• Target: GABA Receptor
• Solubility: DMSO:31 mg/mL (16.49 mM)

Bioactivity

• In Vivo:
  Animal model: 10 weeks old Swiss albino male mice (25-30 g). Dosage: 25, 50, 100 mg/kg. Administration: Oral; daily; for 14 days. Result: Caused a marked induction of oxidative damage in liver tissue as demonstrated by an increased level of TBARS and reduced GSH level.
• In Vitro:
  Cell Viability Assay Cell line: human normal bronchial epithelial cell line 16HBE. Concentration: 2.5, 5, 7.5, 10, 15, 20, 40 μM Incubation time: 12 and 24 hours. Result: Decreased cell viability in a time- and dose-dependent manner wirh IC50s of 11.88 μM and 9.67 μM in 12 and 24 hours, respectively. Apoptosis Analysis Cell line: human normal bronchial epithelial cell line 16HBE. Concentration: 2.5, 5, 10, 20 μM Incubation time: 24 hours. Result: Induced apoptosis and caused chromatin shrinkage and nuclear fragmentation. Western blot analysis. Cell line: human normal bronchial epithelial cell line 16HBE. Concentration: 2.5, 5, 10, 20 μM Incubation time: 12 hours. Result: Increased the amounts of cytochrome-c, caspase-3, cas-pase-9, cleaved-PARP, Bax/Bcl-2.

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

MK-244

Quick Database Links

Gene Symbol

GABA Receptor