Eltoprazine hydrochloride

SKU: orb1299767

Description

Eltoprazine hydrochloride is a serotonin receptor partial agonist with high affinity for 5-HT1A, 5-HT1B, and 5-HT2B receptors (Ki = 40, 52, and 81 nM, respectively). This compound is utilized in preclinical research to investigate serotonergic signaling in models of aggression, Parkinson's disease, and cognitive function.

Research Area

Neuroscience, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 98206-09-8
• MW: 256.73
• Purity: 99.94%
• Formula: C₁₂H₁₇ClN₂O₂
• SMILES: Cl.c1cc2c(c(N3CCNCC3)c1)OCCO2
• Target: 5-HT Receptor
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (7.79 mM);H2O:28 mg/mL (109.06 mM);DMSO:31 mg/mL (120.75 mM)

Bioactivity

• Target IC50:
  5-HT1A:40 nM |5-HT1B:52 nM |5-HT2B:81 nM
• In Vivo:
  Eltoprazine hydrochloride exerts a dose-dependent decrease in aggressive behavior in resident-intruder tests with rats (ID50 = 0.24 mg/kg).

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

DU28853, DU-28853, DU28853 Hydrochloride, DU-28853 Hydrochloride, DU 28853, DU 28853 Hydrochloride, DU 28853 hydrochloride, 5HT Receptor, 5-HT Receptor, 5HTReceptor, 5-hydroxytryptamine Receptor, 5-HT, Eltoprazine, Eltoprazine hydrochloride, Eltoprazine Hydrochloride, Inhibitor, inhibit, Serotonin Receptor

Compound Identifiers

PubChem CID

3025067