Elsulfavirine sodium

SKU: orb3210816

Description

Elsulfavirine sodium (R-1206 sodium) is an orally effective inhibitor of human carbonic anhydrase (CA) and an allosteric inhibitor of HIV-1 non-nucleoside reverse transcriptase (NNRT). It targets and disrupts the interaction between adenylosuccinate lyase (ADSL) and insulin-induced gene proteins INSIG1/2, blocking SREBP-1-mediated de novo lipid synthesis and inhibiting liver cancer cell proliferation. In combination with Lenvatinib, Elsulfavirine sodium exhibits synergistic antitumor effects. Inside the body, it converts to the active metabolite VM1500A, which blocks reverse transcriptase DNA polymerization activity, thereby inhibiting HIV-1 replication. The Ki values for Elsulfavirine sodium against human carbonic anhydrase subtypes I, VII, VI, VA, VB, IX, XIII, XIV range from 1960 nM to 52400 nM. This compound is utilized in research related to HIV-1 infection and liver cancer.

Key Properties

• CAS Number: 867365-40-0
• MW: 652.27
• Formula: C₂₄H₁₇BrCl₂FN₃NaO₅S
• SMILES: [Na].N#CC1=CC(Cl)=CC(OC=2C(Br)=CC=C(C2F)CC(=O)NC3=CC=C(C=C3Cl)S(=O)(=O)NC(=O)CC)=C1
• Target: Reverse Transcriptase,Carbonic Anhydrase,HIV Protease

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

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Gene Symbol

Reverse Transcriptase,Carbonic Anhydrase,HIV Protease