ELN-441958

SKU: orb1306514

Description

ELN-441958 is a highly selective and potent neutral antagonist of the B1 receptor, exhibiting a Ki of 0.26 nM against the agonist [3H]DAKD in IMR-90 cell binding assays. This compound is a valuable research tool for investigating the distinct physiological and pathological roles of the B1 receptor in inflammation, pain, and sepsis using both in vitro and in vivo models.

Research Area

Pharmacology & Drug Discovery

Key Properties

• CAS Number: 913064-47-8
• MW: 501.02
• Purity: 99.88% (May vary between batches)
• Formula: C₂₉H₂₉ClN₄O₂
• SMILES: Clc1cccc2CN(C(=O)c12)c1cccc(c1)C(=O)N1CCC2(CC1)CCN(CC2)c1ccncc1
• Target: Bradykinin Receptor
• Solubility: DMSO:5.02 mg/mL (10.02 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:1 mg/mL (2 mM)

Bioactivity

• Target IC50:
  Bradykinin B1:0.26 nM(ki)

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

B1 Receptor, anti-hyperalgesic, BradykininReceptor, Bradykinin Receptor, low CNS exposure, inhibit, Inhibitor, high oral bioavailability, ELN441958, ELN-441958, ELN 441958

Compound Identifiers

PubChem CID

11848206