Elimusertib hydrochloride(1876467-74-1 free base)

SKU: orb1309943

Description

Elimusertib hydrochloride(1876467-74-1 free base)

Research Area

Molecular Biology, Signal Transduction

Key Properties

• MW: 411.89
• Purity: 98.80% (May vary between batches)
• Formula: C₂₀H₂₂ClN₇O
• SMILES: CN1N=CC=C1C2=CC(N3[C@@H](COCC3)C)=NC4=C(N=CC=C24)C5=CC=NN5.[H]Cl
• Target: ATM/ATR
• Solubility: DMSO:50 mg/mL (121.39 mM);H2O:48 mg/mL (116.54 mM)

Bioactivity

• Target IC50:
  ATR:7 nM
• In Vivo:
  In a variety of xenograft models of ovarian and colorectal cancer, Elimusertib hydrochloride shows potent anti-tumor efficacy in monotherapy and causes complete tumor remission in mantle cell lymphoma models .
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• In Vitro:
  Elimusertib hydrochloride potently inhibits the proliferation of a broad spectrum of human tumor cell lines (median IC50: 78 nM). BAY-1895344 potently suppresses NSC-32065-induced H2AX phosphorylation (IC50: 36 nM) .
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Elimusertib hydrochloride(1876467741 free base), Elimusertib hydrochloride(1876467 74 1 free base), Elimusertib hydrochloride(1876467-74-1 free base), BAY1895344 Hydrochloride, BAY-1895344 hydrochloride, BAY-1895344 Hydrochloride, BAY 1895344 Hydrochloride, ATM, ATR

Compound Identifiers

PubChem CID

129893299