Eleven-Nineteen-Leukemia Protein IN-3

SKU: orb1745135

Description

Eleven-Nineteen-Leukemia Protein IN-3 is a potent, orally bioavailable inhibitor of the ENL YEATS domain with an IC50 of 15.4 nM. It downregulates MYC expression in cells and stabilizes the ENL protein in vitro, making it a valuable chemical probe for researching transcriptional regulation in cancers like leukemia.

Research Area

Cancer Biology, Epigenetics & Chromatin

Key Properties

• CAS Number: 2894121-83-4
• MW: 465.55
• Formula: C₂₈H₂₇N₅O₂
• SMILES: C[C@H]1CCCN1CC1=NC2=CC(NC(=O)C3=CC=C4C(=C3)C3=CC=CC=C3C(=O)N4C)=CC=C2N1
• Target: Epigenetic Reader Domain

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

166642579