Elesclomol

SKU: orb1224957

Description

Elesclomol (STA-4783) is a small-molecule oxidative stress inducer, exerts selective cytotoxicity by increasing intracellular concentrations of reactive oxygen species (ROS) and induces cell death via mitochondrial apoptosisin cancer cells; selectively kills cisplatin-resistant tumor cells through increased ROS, markedly enhances the therapeutic index of paclitaxel against human tumor xenograft models. Ovarian Cancer Phase 2 Clinical.

Key Properties

• CAS Number: 488832-69-5
• MW: 400.5177
• Purity: >98% (HPLC)
• Formula: C₁₉H₂₀N₄O₂S₂
• SMILES: O=C(NN(C)C(C1=CC=CC=C1)=S)CC(NN(C)C(C2=CC=CC=C2)=S)=O
• Target: Apoptosis
• Solubility: DMSO: ≥ 22 mg/mL

Bioactivity

• In Vivo:
  Animal model: Cardiac Ctr1 knockout mice. Dosage: 10 mg/kg. Administration: Subcutaneous injection; every three days from post-natal day 5 to 26 and once weekly until post-natal day 54. Result: Ameliorated severe cardiac pathology with a partial reduction in hypertrophy.
• In Vitro:
  Apoptosis Analysis Cell line: HSB2 cells. Concentration: 200 nM. Incubation time: 18 hours. Result: Increased the number of early and late apoptotic cells.

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

STA-4783 | STA4783 | STA 4783

Quick Database Links

Gene Symbol

Apoptosis