β-Elemonic Acid

SKU: orb1222421

Description

Beta-Elemonic acid exhibits anti-inflammatory effects. Beta-Elemonic acid inhibits proliferation by inducing hypoploid cells and cell apoptosis, the anticancer effects of beta-Elemonic acid are related to the MAPK signaling pathway, ROS activation and glutathione depletion in human A549 lung cancer cells. Beta-Elemonic acid exhibits prolyl endopeptidase inhibitory activities.

Key Properties

• CAS Number: 28282-25-9
• MW: 454.69
• Purity: >98% (HPLC)
• Formula: C₃₀H₄₆O₃
• SMILES: CC(=CCCC(C1CCC2(C1(CCC3=C2CCC4C3(CCC(=O)C4(C)C)C)C)C)C(=O)O)C
• Target: Wnt/beta/catenin
• Solubility: In Vitro: DMSO : 25 mg/mL (54.98 mM)

Bioactivity

• In Vitro:
  β-elemonic acid (1, 3, 10, 20 μM; 24 hours) strongly induces human A549 lung cancer cell apoptosis in a dose- and time-dependent manner. β-elemonic acid (1, 3, 10, 20 μM; 24 hours) exerts potent cytotoxic effects on human NSCLC A549 cells in a dose-dependent manner. The IC50 value following a 24-h exposure to β-elemonic acid was 6.92 μM. β-elemonic acid (20 μM; 24 hours) results in a cell percentage of 58.01% in the G0/G1 phase. β-elemonic acid (1, 3, 10, 20 μM; 24 hours) inhibits phosphorylation of p42/44, MAPK/JNK and p38 in the A549 cells.
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Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

Wnt/beta/catenin