Elbasvir

SKU: orb1302771

Description

Elbasvir is a small molecule NS5A inhibitor used in research for chronic hepatitis C virus (HCV) infection. It is applied in both in vitro virology studies and in vivo animal models to investigate antiviral mechanisms and combination therapy efficacy, supporting the development of direct-acting antiviral regimens.

Research Area

Infectious Disease & Virology, Pharmacology & Drug Discovery, Protein Biochemistry

Key Properties

• CAS Number: 1370468-36-2
• MW: 882.02
• Purity: 99.93% (May vary between batches)
• Formula: C₄₉H₅₅N₉O₇
• SMILES: COC(=O)N[C@@H](C(C)C)C(=O)N1CCC[C@H]1c1ncc([nH]1)-c1ccc2-c3cc4cc(ccc4n3[C@@H](Oc2c1)c1ccccc1)-c1cnc([nH]1)C1CCCN1C(=O)[C@@H](NC(=O)OC)C(C)C
• Target: HCV Protease
• Solubility: DMSO:125 mg/mL (141.72 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (2.27 mM)

Bioactivity

• Target IC50:
  NS5A:2.2 pM (EC50)
• In Vitro:
  Elbasvir potently inhibits hepatitis C virus (HCV) non-structural protein 5A (NS5A) with an EC50 value of 2.2 pM in Huh7 human liver cancer cells expressing pH77S.3/GLuc2A, a cell-culture adapted HCV16 genotype 1a derivative and luciferase reporter, following a 48-hour exposure in vitro [1,2]. NS5A is essential for HCV RNA synthesis and viral assembly, and elbasvir inhibits the assembly of new viral replicase complexes when used at a concentration of 50 pM . It exhibits potent inhibitory activity against a broad range of HCV genotypes with EC50 values of 0.0002-34 nM in Huh7 cells expressing replicons of HCV genotype 4 NS5A and EC50 values of less than 0.2 nM for replicons from all other tested genotypes except 2b [1,3,4]. Formulations containing elbasvir have been used alone and in combination with NS3/4A protease inhibitors in the treatment of HCV.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Elbasvir, HCV Protease, HCVProtease, HCV NS5A, HCV, Hepatitis C virus, MK8742, MK-8742, MK 8742, inhibit, Inhibitor

Compound Identifiers

PubChem CID

137699069