ELB-139

SKU: orb1700661

Description

ELB-139 is a selective agonist of the GABAA receptor. It is utilized in neuroscience research to investigate mechanisms related to neurological disorders, including depression and epilepsy, in both in vitro and in vivo experimental models.

Research Area

Neuroscience, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 188116-08-7
• MW: 277.75
• Purity: 100.00%
• Formula: C₁₄H₁₆ClN₃O
• SMILES: O=C1N=C(N2CCCCC2)CN1C3=CC=C(Cl)C=C3
• Target: GABA Receptor

Bioactivity

• In Vivo:
  ELB139 (10 and 30 mg/kg orally) was active in three different animal models of anxiety in elevated plus maze, light and dark boxes, and Vogel conflict tests.
• In Vitro:
  The IC(50) for the binding site of ELB139 to flunitrazepam in rat forebrain cortical membranes was 1390 nM.In rat hippocampal neurons, ELB139 potentiated GABA-induced currents without maximal effects of diazepam, suggesting partial benzodiazepine agonism.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

GABAReceptor, GABA Receptor, GABAA, ELB 139, ELB139, ELB-139

Compound Identifiers

PubChem CID

11277418