Elagolix sodium

SKU: orb1302154

Description

Elagolix sodium is a potent and selective GnRH receptor antagonist, with reported IC50 and Ki values of 0.25 nM and 3.7 nM, respectively. It is utilized in research to investigate gonadotropin suppression in preclinical models of endometriosis and uterine fibroids, both in vitro and in vivo.

Research Area

Pharmacology & Drug Discovery

Key Properties

• CAS Number: 832720-36-2
• MW: 653.57
• Purity: 99.71%
• Formula: C₃₂H₂₉F₅N₃NaO₅
• SMILES: [Na+].COc1cccc(c1F)-c1c(C)n(Cc2c(F)cccc2C(F)(F)F)c(=O)n(C[C@H](NCCCC([O-])=O)c2ccccc2)c1=O
• Target: GNRH Receptor
• Solubility: DMSO:27.78 mg/mL (42.51 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (3.06 mM);H2O:50 mg/mL (76.5 mM)

Bioactivity

• Target IC50:
  NFAT:5.4 nM|GnRHR:3.7 nM
• In Vivo:
  Elagolix sodium for the treatment of women with moderate to severe endometriosis-associated pain

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Inhibitor, Elagolix, Elagolix sodium, GnRH Receptor, GNRHR, GNRH Receptor, GnRHR, GNRHReceptor, Gonadotropin releasing hormone receptor, NBI56418, NBI-56418, NBI-56418 sodium, NBI 56418, inhibit

Compound Identifiers

PubChem CID

24785956