eIF4A3-IN-9

SKU: orb1744508

Description

eIF4A3-IN-9 is a silvestrol analog that inhibits translation by disrupting eIF4F complex assembly, with EC50 values of 29, 450, and 80 nM against myc-LUC, tub-LUC, and MDA-MB-231 cell growth, respectively. It is a valuable chemical probe for studying oncogenic translation and cancer pathogenesis in cellular models.

Research Area

Cell Biology

Key Properties

• CAS Number: 1402931-71-8
• MW: 505.52
• Formula: C₂₈H₂₇NO₈
• SMILES: O[C@]12[C@]([C@@H]([C@@H](C(OC)=O)[C@H]1O)C3=CC=CC=C3)(OC=4C2=C(OC)C=C(C(N)=O)C4)C5=CC=C(OC)C=C5
• Target: Others,PERK

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

71460662