eIF4A3-IN-18

SKU: orb1744553

Description

eIF4A3-IN-18 is a potent silvestrol analog that inhibits protein synthesis by disrupting eIF4F complex formation, with EC₅₀ values in the low nanomolar range against various cellular targets. It exhibits significant cytotoxicity, particularly against cancer cell lines such as MBA-MB-231 and RMPI-8226, making it a valuable chemical probe for studying translation initiation in cancer pathogenesis research.

Research Area

Cell Biology

Key Properties

• CAS Number: 1402931-84-3
• MW: 500.54
• Formula: C₂₉H₂₈N₂O₆
• SMILES: O[C@]12[C@]([C@@H]([C@@H](C(N(C)C)=O)[C@H]1O)C3=CC=CC=C3)(OC=4C2=C(OC)C=C(C#N)C4)C5=CC=C(OC)C=C5
• Target: PERK,Others

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

71453480