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eIF3e-IN-1

SKU: orb3174439

Description

eIF3e-IN-1 (Compound 209) is an inhibitor of eIF3e with an EC50 of 18.3 μM. It effectively reduces hypoxia-induced accumulation of the HIF1α protein, thereby inhibiting the acute translational response to hypoxia. Additionally, eIF3e-IN-1 significantly suppresses ATF4 protein expression. This compound is applicable in cancer research, including studies on breast cancer.

Research Area

Epigenetics & Chromatin, Metabolism Research

Images & Validation

Key Properties

TargetEpigenetic Reader Domain,HIF/HIF Prolyl-Hydroxylase

Storage & Handling

Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only
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Protocol Information