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EI1

SKU: orb1223315

Description

EI1 is a potent and selective EZH2 inhibitor with IC50 of 15 nM and 13 nM for EZH2 (WT) and EZH2 (Y641F), respectively.

Images & Validation

Key Properties

CAS Number1418308-27-6
MW390.48
Purity>98% (HPLC)
FormulaC23H26N4O2
SMILESCCC(CC)n1ccc2c(cc(cc12)C#N)C(=O)NCc1c(C)cc(C)[nH]c1=O
TargetPAK
SolubilityDMSO : 7.69 mg/mL. 19.69 mM;H2O : < 0.1 mg/mL

Bioactivity

In Vitro
In DLBCL cells, EI1 (KB-145943) inhibits cellular H3K27 methylation and activates Ezh2 target gene p16 expression. In mouse embryonic fibroblasts, EI1 (KB-145943) also inhibit H3K27me3 and cell proliferation. In addition, EI1 (KB-145943) selectively inhibits the growth of DLBCL cells carrying Ezh2 mutation, and causes cell cycle arrest and apoptosis.

Storage & Handling

StorageStorage temperature: -20°C. Stability: ≥ 2 years
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

KB-145943

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    99.98% (May vary between batches)

    1418308-27-6

    390.48

    C23H26N4O2

    25 mg, 50 mg, 100 mg, 1 ml x 10 mM (in DMSO), 200 mg, 5 mg, 10 mg
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EI1 (orb1223315)

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Available Sizes

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200 mg
500 mg
2 mg
$ 100.00
5 mg
$ 140.00
10 mg
$ 200.00
25 mg
$ 350.00
50 mg
$ 530.00
100 mg
$ 760.00