EI1

SKU: orb1223315

Description

EI1 is a potent and selective EZH2 inhibitor with IC50 of 15 nM and 13 nM for EZH2 (WT) and EZH2 (Y641F), respectively.

Key Properties

• CAS Number: 1418308-27-6
• MW: 390.48
• Purity: >98% (HPLC)
• Formula: C₂₃H₂₆N₄O₂
• SMILES: CCC(CC)n1ccc2c(cc(cc12)C#N)C(=O)NCc1c(C)cc(C)[nH]c1=O
• Target: PAK
• Solubility: DMSO : 7.69 mg/mL. 19.69 mM;H2O : < 0.1 mg/mL

Bioactivity

• In Vitro:
  In DLBCL cells, EI1 (KB-145943) inhibits cellular H3K27 methylation and activates Ezh2 target gene p16 expression. In mouse embryonic fibroblasts, EI1 (KB-145943) also inhibit H3K27me3 and cell proliferation. In addition, EI1 (KB-145943) selectively inhibits the growth of DLBCL cells carrying Ezh2 mutation, and causes cell cycle arrest and apoptosis.
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Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

KB-145943

Quick Database Links

Gene Symbol

PAK