EGFR/VEGFR2-IN-9

SKU: orb3173344

Description

EGFR/VEGFR2-IN-9 (Compound 9b) is an inhibitor of VEGFR-2 (IC50 = 1.325 μM) and EGFR (IC50 = 1.891 μM). It significantly suppresses the proliferation of various cancer cell lines, particularly leukemia cells. EGFR/VEGFR2-IN-9 increases the expression levels of Bax, caspase-3, and p53, while decreasing Bcl-2 expression. This compound induces apoptosis and causes cell cycle arrest at the G1 phase. It is suitable for research on anti-tumor angiogenesis and multidrug-resistant cancers.

Research Area

Cardiovascular Research, Cell Biology, Protein Biochemistry, Signal Transduction

Key Properties

• Target: Caspase,EGFR,VEGFR,MDM-2/p53,Bcl-2 Family,Apoptosis

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

Caspase,EGFR,VEGFR,MDM-2/p53,Bcl-2 Family,Apoptosis