EGFR/VEGFR2-IN-3

SKU: orb2802405

Description

EGFR/VEGFR2-IN-3 (compound 9) is a dual inhibitor of EGFR and VEGFR-2 with IC50 values of 0.129 µM and 0.142 µM, respectively, and shows weaker activity against COX-2. This small molecule induces apoptosis and G2/M phase cell cycle arrest in vitro, supporting its investigation in oncology research for anti-angiogenic and anti-proliferative effects.

Research Area

Cardiovascular Research, Cardiovascular Research; Cell Biology, Cell Biology, Signal Transduction

Key Properties

• CAS Number: 710972-61-5
• MW: 510.03
• Formula: C₂₄H₂₀ClN₅O₂S₂
• SMILES: O=C(NNC(=S)NC1=CC=C(C=C1)C)CSC2=NC=3C=CC=CC3C(=O)N2C4=CC=C(Cl)C=C4
• Target: Apoptosis,EGFR,VEGFR

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

4582227