EGFR/HER2-IN-9

SKU: orb1744624

Description

EGFR/HER2-IN-9 is a potent dual inhibitor of EGFR (IC50 = 3.2 nM) and HER2 (IC50 = 14 nM), which also effectively targets the EGFR T790M resistance mutation (IC50 = 8.3 nM). This compound is a valuable research tool for investigating oncogenic signaling in vitro and has shown antitumor efficacy in preclinical cancer models, including non-small cell lung cancer.

Research Area

Cardiovascular Research, Cell Biology, Signal Transduction

Key Properties

• CAS Number: 1637253-79-2
• MW: 513.95
• Formula: C₂₅H₂₅ClFN₅O₄
• SMILES: N(C=1C2=C(C=C(OC)C(NC(/C=C/CN3C[C@@]4([C@](C3)(OCCO4)[H])[H])=O)=C2)N=CN1)C5=CC(Cl)=C(F)C=C5
• Target: Others,EGFR

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

117685125