EGFR/DHFR-IN-2

SKU: orb3027833

Description

EGFR/DHFR-IN-2 (9b) is a dual inhibitor of h-DHFR/EGFR TK, exhibiting IC50 values of 0.192 μM for h-DHFR and 0.109 μM for EGFR. It causes cell cycle arrest at the G1/S phase and induces apoptosis. Additionally, EGFR/DHFR-IN-2 (9b) is a potential inhibitor of CYP2C9 and CYP3A4. This compound can be utilized in cancer research.

Research Area

Cardiovascular Research, Cell Biology, Metabolism Research, Metabolism Research; Cell Biology, Molecular Biology, Signal Transduction

Key Properties

• Formula: C₂₄H₁₆N₄O₅
• Target: Apoptosis,Cytochromes P450,DHFR,EGFR

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

Apoptosis,Cytochromes P450,DHFR,EGFR