EGFR/c-Met-IN-1

SKU: orb3132744

Description

EGFR/c-Met-IN-1 (compound TS-41) is a dual inhibitor targeting EGFR and c-Met, with IC50 values of 68.1 nM for EGFRL858R and 0.26 nM for c-Met. EGFR/c-Met-IN-1 induces apoptosis and cell cycle arrest in A549-P cells, and reduces phosphorylation of EGFR, c-Met, and downstream AKT. This compound effectively inhibits tumor growth both in vitro and in vivo.

Research Area

Cardiovascular Research, Cell Biology, Signal Transduction

Key Properties

• CAS Number: 3020728-68-8
• MW: 568.56
• Formula: C₃₀H₂₅FN₆O₅
• SMILES: O=C(C=C)NC1=CC=2C(=NC=NC2C=C1OC)OC3=CC=C(C=C3F)NC(=O)C=4C(=O)N(C=5C=CC=CC5)N(C4C)C
• Target: EGFR,c-Met/HGFR

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

EGFR,c-Met/HGFR