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EGFR/BRAFV600E-IN-6

SKU: orb3173888

Description

EGFR/BRAFV600E-IN-6 (Compound 7c) is a dual inhibitor of EGFR and BRAFV600E, with IC50 values of 0.12 μM and 0.05 μM, respectively. It exhibits antiproliferative activity against HT-29, MCF-7, A549, and Panc-1 cells, with IC50 values of 8, 4, 6, and 7 μM. EGFR/BRAFV600E-IN-6 activates caspase-3/8/9, upregulates Bax expression, and downregulates Bcl-2 levels, inducing apoptosis and exhibiting antioxidant properties. It is applicable in cancer research, such as studies on colon cancer.

Research Area

Cardiovascular Research, Cell Biology, Protein Biochemistry, Signal Transduction

Images & Validation

Key Properties

TargetCaspase,Bcl-2 Family,EGFR,Raf,Apoptosis

Storage & Handling

Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only
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Protocol Information