EGFR/BRAF-IN-1

SKU: orb1686851

Description

EGFR/BRAF-IN-1 is a potent dual inhibitor of EGFR and BRAF, notably targeting the BRAFV600E mutant with an IC50 of 45 nM. This 2,3-dihydropyrazino[1,2-a]indole-1,4-dione derivative demonstrates potent anti-proliferative activity (GI50=35 nM) in cancer cells and exhibits antioxidant properties, making it a valuable tool compound for oncology research in vitro.

Research Area

Cardiovascular Research, Cell Biology, Signal Transduction

Key Properties

• MW: 481.97
• Formula: C₂₆H₂₈ClN₃O₄
• Target: Raf,Others,EGFR

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

Raf,Others,EGFR