EGFR T790M/L858R-IN-9

SKU: orb2945235

Description

EGFRT790M/L858R-IN-9 (Compound 8) is a potent and selective inhibitor of the EGFR-L858R/T790M mutant kinase, with an IC50 of 6.4 nM. It effectively blocks mutant EGFR phosphorylation and suppresses the proliferation of NSCLC cells in vitro, serving as a valuable tool for targeted cancer therapy research.

Research Area

Cardiovascular Research, Signal Transduction

Key Properties

• MW: 517.603
• Formula: C₂₆H₂₇N₇O₃S
• SMILES: CCC(=O)N1CCN(CC1)C2=CC(=CC=C2)OC3=NC=CC(=N3)NC4=NN=C(S4)C5=CC=C(C=C5)OC
• Target: EGFR

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

172677070