EGFR T790M/L858R-IN-8

SKU: orb2564606

Description

EGFRT790M/L858R-IN-8 (compound 9) is a selective inhibitor of the EGFR T790M/L858R mutant with an IC50 of 56.8 µM. It serves as a valuable research tool for investigating resistant non-small cell lung cancer (NSCLC) in biochemical assays, though it exhibits limited antiproliferative activity in cell lines like A549 and NCI-H1975.

Research Area

Cardiovascular Research, Cell Biology, Signal Transduction

Key Properties

• CAS Number: 333419-97-9
• MW: 359.17
• Formula: C₁₆H₁₁BrN₂O₃
• SMILES: O=C(NC=1C=CC=C(Br)C1)C=2C(=O)NC=3C=CC=CC3C2O
• Target: EGFR

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

54678831