EGFR mutant-IN-2

SKU: orb2566340

Description

EGFR mutant-IN-2 (D51) is a potent, selective inhibitor of EGFR triple mutants L858R/T790M/C797S and del19/T790M/C797S, with IC50 values of 14 nM and 62 nM, respectively. It demonstrates favorable pharmacokinetics, safety, and in vivo stability, supporting its use in preclinical research for studying resistant non-small cell lung cancer (NSCLC) models both in vitro and in vivo.

Research Area

Cardiovascular Research, Signal Transduction

Key Properties

• CAS Number: 2770009-06-6
• MW: 556.6
• Formula: C₂₇H₂₇F₃N₆O₂S
• SMILES: C(F)(F)(F)C=1C(C=2C=3C(N(S(CC)(=O)=O)C2)=CC=CC3)=NC(NC=4C=C5C(=CC4)N(CCN(C)C)C=C5)=NC1
• Target: EGFR

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

163288439