EGFR kinase inhibitor 3

SKU: orb2566343

Description

This C-linked, dual-action EGFR kinase inhibitor targets both ATP and allosteric sites, demonstrating potent sub-nanomolar activity against key mutations including L858R, T790M, and C797S. It is a valuable research tool for investigating resistance mechanisms and evaluating therapeutic strategies in both cellular and preclinical models of EGFR-driven cancers.

Research Area

Cardiovascular Research, Pharmacology & Drug Discovery; Cell Biology, Signal Transduction

Key Properties

• CAS Number: 2922402-03-5
• MW: 575.64
• Formula: C₃₁H₂₅N₇O₃S
• SMILES: S(C)C=1NC(=C(N1)C=2C=C(NC(C)=O)N=CC2)C3=CC(NC(=O)C4=C5C(NC=6C(C(=O)N5)=CC=CC6)=CC=C4)=CC=C3
• Target: EGFR

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

172653059