EGFR-IN-23

SKU: orb1744430

Description

EGFR-IN-23 (Compound 8 from WO2021244502A1) is a potent and selective EGFR tyrosine kinase inhibitor. It exhibits significant activity against the EGFR-DEL19/T790M/C797S triple mutant, with an IC50 of 8.05 nM in BaF3 cellular assays. This inhibitor is a valuable research tool for studying resistant non-small cell lung cancer (NSCLC) in both in vitro and in vivo models.

Research Area

Cardiovascular Research, Cell Biology, Signal Transduction

Key Properties

• CAS Number: 2747133-37-3
• MW: 775.68
• Formula: C₃₆H₄₄BrN₁₀O₃P
• SMILES: N(C1=CC(=C(C=C1OC)N2CCC(CN3CCCOCC3)CC2)C=4C=NN(C)C4)C=5N=C(NC6=C(P(C)(C)=O)C7=C(C=C6)N=CC=N7)C(Br)=CN5
• Target: EGFR,Others

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

163196269