EGFR kinase inhibitor 1

SKU: orb1686391

Description

This potent small molecule EGFR inhibitor exhibits high activity against wild-type (IC50: 37 nM) and L858R/T790M mutant (IC50: 1.7 nM) forms, but not the C797S triple mutant. It demonstrates anti-proliferative effects in vitro by inducing G0/G1 cell cycle arrest and apoptosis, and it has shown anti-tumor and anti-metastatic potential in relevant research models.

Research Area

Cardiovascular Research, Cell Biology, Pharmacology & Drug Discovery; Cell Biology, Signal Transduction

Key Properties

• CAS Number: 2413958-04-8
• MW: 521.61
• Formula: C₃₀H₃₁N₇O₂
• SMILES: N(C(C=C)=O)C1=C(C=C(OC)C(NC=2N=C(C=CN2)C=3C=4C(N(C)C3)=CC=CC4)=C1)N5C(CN(C)C)=CC=C5
• Target: Apoptosis,Others,EGFR

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

165412576