EGFR-IN-99

SKU: orb1694217

Description

EGFR-IN-99 (JBJ-03-142-02) is a selective small molecule inhibitor targeting EGFR and HER2 exon 20 insertion mutations. It demonstrates potent antiproliferative activity in non-small cell lung cancer (NSCLC) cell lines and has shown efficacy in preclinical in vivo tumor models, supporting its use as a research tool for targeted oncology studies.

Research Area

Cardiovascular Research, Signal Transduction

Key Properties

• CAS Number: 2068806-31-3
• MW: 487.49
• Purity: 97.75%
• Formula: C₂₅H₂₂FN₇O₃
• SMILES: O=C(C=C)NC1=CC=CC(=C1)N(C(=O)OCC2=CC=C(F)C=C2)C3=NC(=NC=C3)NC=4C=NN(C4)C
• Target: HER,EGFR
• Solubility: DMSO:1 mg/mL (2.05 mM)

Storage & Handling

• Storage: store at low temperature,keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

JBJ 03 142 02, JBJ0314202, JBJ-03-142-02, HER2, EGFR

Compound Identifiers

PubChem CID

126496758