EGFR-IN-8

SKU: orb1309716

Description

EGFR-IN-8

Research Area

Cardiovascular Research, Signal Transduction

Key Properties

• CAS Number: 2407957-87-1
• MW: 662.02
• Purity: 99.51%
• Formula: C₃₂H₂₃ClF₃N₇O₄
• SMILES: FC(F)(F)c1cc(NC(=O)Nc2cccc(c2)-c2nc(no2)-c2ccc(NC(=O)c3cccnc3)cc2Cl)ccc1NC(=O)C1CC1
• Target: c-Met/HGFR,EGFR
• Solubility: DMSO:< 1 mg/mL (insoluble or slightly soluble)

Bioactivity

• In Vivo:
  EGFR-IN-8 (50,150 mg/kg; oral gavage) exhibits suppression (29% and 60%, respectively) of H1975 xenograft tumor growth in a dose-dependent manner.
• In Vitro:
  In A549, PC9, H1975, CL68, and CL97 cells, EGFR-IN-8 (0-0.6 μM; 48 hours) suppresses the expression of EGFR and c-Met in these five cell lines irrespective of their mutational status. EGFR-IN-8 (0-20 μM; 24, 48, 72 hours) exhibits a time- and dose-dependent inhibitory effect on the viability of A549, PC9, H1975, CL68, and CL97 cells at different time intervals, with IC50 values ranging from 0.3 to 0.6 μM and 0.2-0.5 μM after 48 and 72 h of treatment respectively.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

c-Met/HGFR, cMet/HGFR, c-Met, cMet, inhibit, Epidermal growth factor receptor, ErbB-1, EGFRIN8, EGFR-IN-8, EGFR IN 8, EGFR, Inhibitor, HER1, HGFR

Compound Identifiers

PubChem CID

139035057