EGFR-IN-55

SKU: orb1686345

Description

EGFR-IN-55 is a potent small molecule inhibitor targeting both wild-type EGFR (IC50 = 70 nM) and the resistant EGFRL858R/T790M mutant (IC50 = 3.9 nM). It demonstrates anticancer activity by inducing G0/G1 phase cell cycle arrest in NCI-H1975 cells, making it a valuable tool for in vitro research in non-small cell lung cancer and kinase signaling pathways.

Research Area

Cardiovascular Research, Cell Biology, Signal Transduction

Key Properties

• CAS Number: 2057423-46-6
• MW: 526.42
• Formula: C₂₅H₂₅Cl₂N₇O₂
• SMILES: N(C1=CC=C(C=C1)N2CCN(C(C)=O)CC2)C=3N=C(NC4=CC(NC(C(=C)Cl)=O)=CC=C4)C(Cl)=CN3
• Target: EGFR,Others

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

141464430