EGFR-IN-49

SKU: orb1687925

Description

EGFR-IN-49 is a selective small molecule inhibitor targeting EGFR T790M and T790M/L858R mutants with IC50 values of 65.0 nM and 13.6 nM, respectively. It induces dose-dependent apoptosis and is a useful tool compound for in vitro and in vivo studies of non-small cell lung cancer resistance mechanisms.

Research Area

Cardiovascular Research, Cell Biology, Signal Transduction

Key Properties

• CAS Number: 2459932-81-9
• MW: 413.45
• Formula: C₂₂H₁₅N₅O₂S
• SMILES: O(C1=C2C(=NC(NC3=CC(C#N)=CC=C3)=N1)C=CS2)C4=CC(NC(C=C)=O)=CC=C4
• Target: Others,EGFR

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

162669174