EGFR-IN-201

SKU: orb3210096

Description

EGFR-IN-201 is a potent EGFR inhibitor with an IC50 of 0.091 μM for wild-type EGFR. For mutant EGFR variants, EGFRT790M, EGFRL858R, and EGFRC797S, it exhibits IC50 values of 0.147 μM, 0.221 μM, and 0.703 μM, respectively. EGFR-IN-201 also inhibits downstream signaling proteins AKT1 (IC50 = 0.225 μg/mL) and ERK1 (IC50 = 0.705 μg/mL). The compound can induce G0/G1 phase cell cycle arrest, apoptosis, and low-level necrosis in cancer cells. EGFR-IN-201 is applicable in cancer research, including studies on colon cancer.

Key Properties

• CAS Number: 3103654-99-2
• MW: 340.40
• Formula: C₁₇H₁₆N₄O₂S
• SMILES: O=C1N=C(SC1=CC2=CC=C(OC)C=C2)NN=C(C3=CC=CN3)C
• Target: Caspase,Bcl-2 Family,Akt,ERK,EGFR,Apoptosis

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

Caspase,Bcl-2 Family,Akt,ERK,EGFR,Apoptosis