EGFR-IN-200

SKU: orb3211275

Description

EGFR-IN-200 is an inhibitor targeting EGFR, TNF-α, and the IL-6/GP130 complex, effectively interacting with human EGFR (IC50=0.03 μM), TNF-α (IC50=3.1 μM), and the IL-6/GP130 complex (IC50=1.6 μM). It binds the ATP pocket of EGFR, the trimer interface of TNF-α, and the cytokine-receptor interface of IL-6/GP130, inducing cell cycle G2/M phase arrest, apoptosis, and antiproliferative effects. EGFR-IN-200 is characterized by high gastrointestinal absorption and low blood-brain barrier permeability, adhering to Lipinski's rules. It is applicable in research on lung cancer and breast adenocarcinoma.

Key Properties

• CAS Number: 3102899-89-5
• MW: 499.95
• Formula: C₂₈H₂₂ClN₃O₄
• SMILES: N#CC1=C(N=C(C=C1C=2C=CC=CC2Cl)C=3C=CC(OC)=CC3)OCC(=O)NC=4C=CC=CC4OC
• Target: Apoptosis,Interleukin,TNF,EGFR

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

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Gene Symbol

Apoptosis,Interleukin,TNF,EGFR