EGFR-IN-189

SKU: orb3174870

Description

EGFR-IN-189 (Compound 7) is a selective covalent inhibitor of the epidermal growth factor receptor (EGFR) with an IC50 value of 200 nM. It effectively inhibits the C797S mutant form of EGFR, suppresses cancer cell proliferation, and inhibits phosphorylation of EGFR and downstream ERK1/2. EGFR-IN-189 is applicable in non-small cell lung cancer research.

Key Properties

• CAS Number: 3037398-18-5
• MW: 438.54
• Formula: C₂₆H₂₆N₆O
• SMILES: O=C1C=C(C#C)C=2C=NC(=NC2N1C=3C=CC=CC3)NC4=CC=C(C=C4)N(C)CCN(C)C
• Target: EGFR

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

EGFR