EGFR-IN-187

SKU: orb3174085

Description

EGFR-IN-187 (Compound 4d) is a selective EGFR inhibitor with an IC50 of 25.41 μM. It exhibits inhibitory activity against PANC-1 and A549 cells with IC50 values of 0.067 μM and 2.29 μM, and selectivity indices (SI) of 1521 and 21, respectively. EGFR-IN-187 causes cancer cells to arrest in the S and G2/M phases and induces apoptosis and autophagy. It upregulates the expression of CCNE1, Bax, LC3B-II, and P27, while downregulating CCNA1 and Bcl-2 levels. EGFR-IN-187 is applicable for cancer research, including studies on lung cancer.

Key Properties

• Target: CDK,ATG,EGFR,Bcl-2 Family,Apoptosis,Autophagy

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

CDK,ATG,EGFR,Bcl-2 Family,Apoptosis,Autophagy