EGFR-IN-186

SKU: orb3174502

Description

EGFR-IN-186 is a potent EGFR inhibitor with an IC50 value of 0.065 µM. It also exhibits inhibitory activity against EGFRL858R (IC50= 0.528 µM) and EGFRT790M (IC50= 0.465 µM). EGFR-IN-186 induces apoptosis by increasing levels of Bax and caspase-3, while decreasing the expression of Bcl-2. This compound can be utilized in non-small cell lung cancer (NSCLC) research.

Key Properties

• Target: Apoptosis,Caspase,Bcl-2 Family,EGFR

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

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Gene Symbol

Apoptosis,Caspase,Bcl-2 Family,EGFR