EGFR-IN-186

SKU: orb3174502

Description

EGFR-IN-186 is a potent EGFR inhibitor with an IC50 value of 0.065 µM. It also exhibits inhibitory activity against EGFRL858R (IC50= 0.528 µM) and EGFRT790M (IC50= 0.465 µM). EGFR-IN-186 induces apoptosis by increasing levels of Bax and caspase-3, while decreasing the expression of Bcl-2. This compound can be utilized in non-small cell lung cancer (NSCLC) research.

Research Area

Cardiovascular Research, Cell Biology, Protein Biochemistry, Signal Transduction

Key Properties

• Target: Caspase,Bcl-2 Family,EGFR,Apoptosis

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

Caspase,Bcl-2 Family,EGFR,Apoptosis