EGFR-IN-176

SKU: orb3173382

Description

EGFR-IN-176 is an orally active and ATP-competitive inhibitor specifically targeting mutated forms of EGFR, particularly the C797S-mediated EGFR triple mutant. It effectively inhibits the activation of the AKT signaling pathway and induces apoptosis in Ba/F3 and PC-9 cells, which express EGFR19del/T790M/C797S or EGFRL858R/T790M/C797S mutations, respectively. EGFR-IN-176 selectively blocks EGFR signaling in cell lines with the EGFR triple mutation, without affecting wild-type EGFR expressed in A431 cells. Additionally, EGFR-IN-176 effectively inhibits ALK enzyme activity with an IC50 of less than 0.5 nM and is useful in the study of non-small cell lung cancer.

Key Properties

• CAS Number: 2754394-10-8
• MW: 699.88
• Formula: C₃₅H₄₅N₁₁O₃S
• SMILES: O=S(=O)(N(C1=C2N=CC=NC2=CC=C1NC=3N=C(N=C4NC=CC43)NC=5C=C(C(=CC5OC)N6CCC(N7CCN(C)CC7)CC6)CC)C)C
• Target: Apoptosis,ALK,Akt,EGFR

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

Apoptosis,ALK,Akt,EGFR