EGFR-IN-173

SKU: orb3173365

Description

EGFR-IN-173 is an orally active, broad-spectrum mutant EGFR tyrosine kinase inhibitor that targets EGFR19del, L858R/T790M, and the triple mutation C797S, with an IC50 of 1.19 nM, effectively inhibiting the EGFR19del/T790M/C797S mutant. It demonstrates over 100-fold selectivity for mutated EGFR compared to the wild type [wild type IC50= 19.362 μM]. EGFR-IN-173 significantly suppresses cell migration, induces apoptosis in non-small cell lung cancer (NSCLC) cells, inhibits EGFR phosphorylation, and blocks downstream pathways (MAPK/ERK, AKT, STAT3). It shows antitumor activity in NSCLC and Ba/F3 xenograft models and is applicable in NSCLC research.

Key Properties

• Target: Apoptosis,STAT,Akt,ERK,p38 MAPK,EGFR

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

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Gene Symbol

Apoptosis,STAT,Akt,ERK,p38 MAPK,EGFR