EGFR-IN-167

SKU: orb3135902

Description

EGFR-IN-1671 is a selective EGFR inhibitor with an IC50 value of 0.19 nM. It effectively inhibits various EGFR mutants, showing IC50 values of 0.109 nM for EGFR(L858R), 0.75 nM for EGFR(C797S), and less than 0.05 nM for EGFR(del19). EGFR-IN-1671 covalently binds to the catalytically conserved lysine of EGFR in live mammalian cells. By inhibiting EGFR autophosphorylation, this compound demonstrates excellent antiproliferative activity. EGFR-IN-1671 is applicable in research on non-small cell lung cancer (NSCLC), glioblastoma, and various solid tumors.

Research Area

Cardiovascular Research, Cell Biology, Signal Transduction

Key Properties

• CAS Number: 3052761-67-5
• MW: 467.47
• Formula: C₂₀H₂₂FN₃O₇S
• SMILES: O=S(=O)(F)OC1=CC=CC(=C1)NC=2N=CN=C3C=C(OCCOC)C(OCCOC)=CC32
• Target: EGFR

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

EGFR