EGFR-IN-154

SKU: orb3028970

Description

EGFR-IN-154 (compound 4c) is an EGFR inhibitor with EC₀ values of 0.16 μM for EGFRDel19, 21.73 μM for EGFR WT, and 41.56 μM for EGFRL858R. This compound exhibits anticancer activity across various cancer cell lines. EGFR-IN-154 induces mitochondrial apoptosis, reduces pERK1/2 and pAkt levels, and increases pJNK and pp38 levels.

Research Area

Cardiovascular Research, Cell Biology, Signal Transduction

Key Properties

• Target: JNK,Akt,p38 MAPK,EGFR,ERK

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

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Gene Symbol

JNK,Akt,p38 MAPK,EGFR,ERK