EGFR-IN-152

SKU: orb3174925

Description

EGFR-IN-152 (compound D4) is a potent inhibitor of the EGFR tyrosine kinase and exhibits significant inhibitory activity against the EGFRL858R/T790M/C797S mutations (IC50= 40 nM). It induces cell cycle arrest at the G0/G1 phase and apoptosis, thereby hindering the clonogenic growth and proliferation of non-small cell lung cancer (NSCLC) cells. EGFR-IN-152 is applicable for NSCLC research.

Research Area

Cardiovascular Research, Cell Biology, Signal Transduction

Key Properties

• CAS Number: 2463197-87-5
• MW: 573.72
• Formula: C₂₉H₃₅N₉O₂S
• SMILES: N(C=1N(C=2C(N1)=CN=C(NC3=CC=C(C=C3)N4CCN(C)CC4)N2)[C@@H]5CN(S(=O)(=O)C6CC6)CC5)C7=CC=CC=C7
• Target: EGFR,Apoptosis

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

EGFR,Apoptosis